Nodulosis–arthropathy–osteolysis syndrome
A RARE, AUTOSOMAL RECESSIVE INHERITED SYNDROME CAUSED BY MUTATIONS IN THE MMP2 GENE. IT IS CHARACTERIZED BY THE PRESENCE OF MULTIPLE, PAINLESS SUBCUTANEOUS NODULES, OSTEOLYSIS PARTICULARLY IN THE HANDS AND FEET, OSTEOPOROSIS, AND ARTHROPATHY.
Nodulosis-arthropathy-osteolysis syndrome; NAO syndrome; Nodulosis
Nodulosis–arthropathy–osteolysis syndrome is a cutaneous condition that shares features with juvenile hyaline fibromatosis.